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Research has shown that raising the legal age of sale to 21 would likely reduce youth tobacco initiation and use, said Corey Fitzgerald, Army Public Health Center public health social worker

Violations can lead to prosecution under the Tobacco Control Order, with offenders facing fines and imprisonment (historically penalties for tobacco offenses are severe, though exact vape fines are not publicly detailed)

Food and Drug Administration and the Truth campaign from Truth Initiative

Nicotine was a factor in Christian Bale's extreme transformation for The Machinist, where he lost 62lbs or about a third of his bodyweight by surviving on a diet of an apple and black coffee a day and taking up smoking