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For E-cigarette vapour, we have shown increased ROS and superoxide formation already in vivo (by DHE fluorescence microtopography as well as HPLC analysis) in E-cigarette vapour exposed mice, even showing prevention of oxidative stress and adverse cardiovascular effects in E-cigarette vapour exposed mice with genetic deficiency of phagocytic NADPH oxidase (Nox2 knockout) [41]

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