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The initial symptoms are mainly due to stimulatory effects and include nausea and vomiting, excessive salivation, abdominal pain, pallor, sweating, hypertension, tachycardia, ataxia, tremor, headache, dizziness, muscle fasciculations, and seizures

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most of them were located within 2-kb regions of interrogated CpGs, but some were further apart or even on different chromosomes (Numata et al., 2012)