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Trouble sleeping and restlessness Insomnia, fatigue, and restlessness are all common side effects of nicotine withdrawal, according to a 2019 review of literature

Smoking-driven restructuring of gastrointestinal microbial communities Beyond the respiratory tract, cigarette smoke exerts profound systemic effects that extend to the gastrointestinal ecosystemthe largest and most metabolically active microbial reservoir in the human body

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N Z Med J 123:6473