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15 Patients usually begin one to two weeks before their quit date, with a one week dose escalation period, followed by 11 weeks of maintenance treatment:* 15 Step 1 set a quit date Step 2 initiate varenicline one to two weeks before this quit date, initially at a dose of 500 micrograms, once daily, for the first three days Step 3 increase the dose to 500 micrograms, twice daily, for four days Step 4 increase the dose to 1 mg, twice daily Step 5 most patients should continue with this maintenance dose for 11 weeks

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It was not until 1912 that Nicholas II recognized Paul and Olgas morganatic marriage, which encouraged the couple to move back to Russia in 1914