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We searched for the latest estimates for x countries included in our previous study as well as those additional y countries where estimates have been made available since 2014 for the first time

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The combination of significantly lower levels of known carcinogens, reduced respiratory irritants, and sharply diminished carbon monoxide exposure supports their classification as less harmful alternatives. This review adds to a growing body of independent scientific evidence that switching completely from smoking to regulated smoke-free products can dramatically reduce a smokers exposure to the chemicals most closely linked to cancer, heart disease, and other devastating tobacco-related illnesses