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This structured model-building approach ensures model stability and reduces residual confounding 14

From its origins in Durham, North Carolina under the Liggett & Myers American Tobacco Company, to its iconic 1940s and 1950s campaigns with Bing Crosby, Perry Como, Bob Hope, and Ronald Reagan on NBC radio programs, to todays modern range featuring the Chesterfield Switch, Remix, Double Mix, Shuffle, and a full spectrum of flavours from the bold Original Red to the smooth Crown Blue this brand has consistently satisfied smokers across generations and continents

doi:10.1186/s12967-015-0690-y CrossRef Coker I, Colak A, Gunaslan Hasturk A, Yildiz O, Turkon H, Halicioglu O

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