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In 2016, the Tobacco Products Directive (TPD) was introduced for EU member states, and with that came a raft of brand-new regulation for the manufacturing and sale of tobacco products, as well as e-cigarettes and other vaping products

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However, it is crucial to emphasize that reducing the nicotine in cigarettes does not reduce their toxicity, because the harm comes from chemicals other than nicotine, especially chemicals formed during combustion

A systems toxicology approach for comparative assessment: biological impact of an aerosol from a candidate modified-risk tobacco product and cigarette smoke on human organotypic bronchial epithelial cultures