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The number of manufactured cigars, on the other hand, continued to rise, until in the 1960s, with 1.1 million nationally consumed cigars, the absolute pinnacle was reached
Recent advances, primarily based on three landmark clinical studies, namely, Nix-TB, ZeNix, and TB PRACTECAL (Conradie et al., 2020
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Whilst their mode of use resembles that of traditional snus, they differ substantially in composition (tobacco-free), manufacturing processes and regulatory classification (47, 48)
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