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This is evident behaviourally as THC and nicotine have opposite effects on memory and cognition in humans with THC impairing and nicotine facilitating performance (Gray et al

The Nrf2sMAF heterodimer binds to the antioxidant response element (ARE), which leads to the transcription of genes encoding antioxidant and detoxification enzymes such as SOD, CAT, GP X , heme oxygenase 1 (HO-1), NAD(P)H quinone dehydrogenase 1 (NQO1), which protect cells from oxidative stress and toxins (124126) (Figure 3)

When cannabis is consumed, whether through smoking, vaporizing, or ingesting, the cannabinoids interact with the body's endocannabinoid system (ECS)