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However, PAHs and their metabolites, which are relatively strong the aryl hydrocarbon receptor (AhR) ligands, exert both anti-estrogenic and estrogenic effects subsequently inhibiting or enhancing estrogenic signaling via crosstalk between AhR and estrogen receptors (ERs) or interfere with the AhR-controlled enzymes [41, 44]

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Both sedatives and marijuana have been shown to induce drowsiness, so mixing them may worsen these effects

By 2014, city officials found smuggled cigarettes "in 48 percent of bodegas visited in recent inspections," according to a later Times story