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had a clinically significant abnormal finding on the physical examination, medical history, vital signs, electrocardiogram, or clinical laboratory results

Some of the long-term effects of smoking that may be experienced include: increased risk of stroke and brain damage eye cataracts, macular degeneration, yellowing of whites of eyes loss of sense of smell and taste yellow teeth, tooth decay and bad breath cancer of the nose, lip, tongue and mouth possible hearing loss laryngeal and pharyngeal cancers contributes to osteoporosis shortness of breath coughing chronic bronchitis cancer triggering asthma emphysema heart disease blockages in blood supply that can lead to a heart attack high blood pressure (hypertension) myeloid leukaemia, a cancer that affects bone marrow and organs that make blood stomach and bladder cancers stomach ulcers decreased appetite grey appearance early wrinkles slower healing wounds damage to blood vessel walls increased likelihood of back pain increased susceptibility to infection lower fertility and increased risk of miscarriage irregular periods early menopause damaged sperm and reduced sperm impotence

If you live with a person who smokes, you can reduce secondhand smoke by opening windows and using an air purifier

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