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A third limitation is that, because of the method of drug delivery, nicotine dose was not titrated for participant body weight, resulting in varying plasma nicotine concentrations

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Heres more from the Associated Press: The higher age limit, part of a package of anti-tobacco bills, won approval despite intense lobbying from tobacco interests and fierce opposition from many Republicans, who said the state should butt out of peoples personal health decisions, even if they are harmful Opponents said American law and custom has long accepted that people can make adult decisions on their 18th birthday and live with the consequences