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But due to their very high levels of carcinogens, or cancer-causing agents, American smokeless tobacco products are tied closely to cancers of the stomach, mouth, and pancreas, as well as high blood pressure, blood clotting, and heart disease, according to the American Cancer Society
Few chewing tobacco and Zarda had the lowest levels of un-protonated nicotine (0.100.52% and 0.150.21%, respectively), whereas Gul, Gudhaku, and Khaini had the highest levels, ranging from 95.33 to 99.12%
Studies suggest this can cause the phenomenon of increased nicotine dependence and lower smoking cessation rate in darker pigmented individuals