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On his World Wide Words blog, Michael Quinion suggests that it may have had to do with snuffs largest user demographic: wealthy men who would be able to appreciate the quality of snuff and distinguish between examples of different value. What we do know is that up to snuff had entered the British lexicon by 1807, when it appeared in a London newspaperthe earliest known written mention of the phrase, according to Merriam-Webster

Most patients report referred ear pain about a week after their tonsillectomy

The toxic effects of ST on female reproductive physiology have been summarized in Table 2

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