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2 Only a few states are funding their tobacco control programs at the levels currently recommended by the Centers for Disease Control and Prevention (CDC), meaning that tobacco company marketing efforts are largely occurring without effective, well-funded state tobacco control programs to respond

Establishments are required to post signs stating that sales to underage persons are prohibited.6,7 Underage persons are prohibited from buying tobacco products and electronic smoking devices, including e-cigarettes.6,7, 9 The sale or distribution of tobacco products to underage persons is prohibited (unless the person has attained 18 years of age as of July 1, 2018).9 Employees of e-cigarette retailers must be at least 17 years of age

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Only 575 patients (UC: 297 and CD: 278) with complete information of comorbidities (hypertension, diabetes, hyperlipidemia) and aged from 12 to 64 years old were enrolled with the median follow up time as 100 and 92.5 months, respectively