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25 By 1976, the RJR Market Research Department (MRD) had joined the Research and Development (R&D) effort with a clear statement of their intent to maximise the nicotine satisfaction while maintaining high profitability by using conventional filters and packaging
21 Similarly, nicotine has been shown to reduce blood flow in fingers and increase systemic blood pressure, a mechanism that could rationally explain the association of impaired stain removal and PAD
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