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Supplementation with citrulline, but not ornithine or the nitric oxide donor sodium nitrite, restored the growth of the CR hi cell lines in these arginine-free conditions (Figure 6A), confirming that the mitochondrial component, rather than the cytosolic component of the urea cycle pathway, was unable to support continued proliferation in the absence of exogenous arginine
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Acknowledgments This study was supported by F32AA024018, AA-11431 and AA-12908 from the National Institutes of Health
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