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When evaluating the effect of menthol on the barrier function of the LES we consider the inspiratory augmentation of the LES a relevant parameter as it is correlated with the positive pH metry findings [12, 22]

Constipation can be severe and lead to an increased risk of intestinal obstruction and ileus (MHRA warning 2017 Clozapine: reminder of potentially fatal risk of intestinal obstruction, faecal impaction, and paralytic ileus )

Cough was the most common reported symptom among 16% of study participants, with 10% reporting shortness of breath and phlegm