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Volkow, the director of the National Institute on Drug Abuse, It is urgent that teens understand the possible effects of vaping on overall health, the development of the teen brain and the potential for addiction. Vaping May Lead to Use Of Other Substances In 2014, the New England Journal of Medicine published a study on teen e-cigarette use, written by husband-and-wife team Eric and Denise Kandel, who are the originators of the "gateway drug" hypothesis