difficile) Avoid colonoscopy in toxic megacolon Management Induction of remission: Mildmoderate: 5-ASA (oral rectal) Moderatesevere: Corticosteroids Severe/refractory: Biologics (anti-TNF, anti-integrin, JAK inhibitors) Maintenance: 5-ASA Azathioprine / biologics (if steroid-dependent) Complications Toxic megacolon Severe bleeding Perforation Colorectal cancer (risk with duration & extent) Surgical Indications Refractory disease Dysplasia or carcinoma Toxic megacolon Massive hemorrhage Colectomy is curative Continuous disease, rectum always involved Limited to mucosa Associated with PSC Smoking appears protective (opposite of Crohns) To view or add a comment, sign in Systemic Lupus Erythematosus (SLE) Definition: SLE is a chronic autoimmune disease in which the immune system attacks multiple organ systems, causing inflammation and tissue damage
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