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When examining differences between age groups and over time using repeat cross-sectional data such as this, consider that some of the differences between age groups could also be due to cohort effects (as well as age effects), in addition to changes over time

Our multimodal meta-analytic outcomes add to a growing literature implicating the vmPFC, insula, and thalamus as contributors to the initiation, escalation, maintenance, and/or cessation of cigarette smoking

Snowman : carrot + snow, carrot + snowball, human + snow, or 2x snowball