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While the Flavor and Extracts Manufacturers Association considers many flavors to be GRAS in food products, at their levels of intended use, these chemicals could still be harmful when they are aerosolized and inhaled, as such ingredients are not safety tested for exposure routes other than ingestion (Barrington-Trimis et al., 2016

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In addition, exposure to tobacco smoke extract (TSE) exposure can cause human macrophages to release EVs (including exosomes and ectosomes), which contribute to the release of matrix metalloproteinase 14 (MMP14) and may contribute to emphysema [102, 103]