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Less serious side effects of Mirena can include: pain, bleeding, or dizziness during and after placement changes in menstrual bleeding patterns, such as heavier periods when you first start Mirena, bleeding between periods, or missed periods increased pain and cramps during your period headache or migraine acne tiredness breast tenderness nausea inflammation of your vagina that can cause pain and vaginal discharge enlarged ovaries cysts on your ovaries hair loss expulsion (the device coming out of your vagina on its own) decreased sexual desire unwanted hair growth Serious side effects Mirena may cause some serious side effects