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Nicotine also stimulates the brain to release dopamine, leading to pleasurable feelings and a sense of well-being, but this effect is short-lived and often followed by tiredness and sluggishness

Your liver quickly breaks down nicotine into cotinine

Because of the long time that nicotine and other products of the burning of tobacco remain in the liver and urinary bladder, the author believes that primary cancer of these organs also is sometimes caused by tobacco

If you're a smokeless-tobacco user, you should always follow the product directions carefully and ask a clinician whether combination therapy suits your specific nicotine exposure, current medications, and overall health history