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The enzyme allantoin is present in mammals and breaks down uric acid into allantoin, whereas during natural evolution, humans have lost the functional gene encoding allantoin through natural selection by genetic mutation and therefore cannot break down uric acid into soluble allantoin and thus excrete it from the body 4

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Four days after the operation, Walters' spokeswoman, Cindi Berger, said that the procedure to fix the faulty heart valve "went well, and the doctors are very pleased with the outcome"

The estimated annual percentage change (EAPC) in ASMR was computed using a log-linear regression model, providing a summary measure of the average annual rate of change