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- poor harvesting conditions : the harvested leaves are very fragile, the slightest contusions or too long waiting in the field will have repercussions during curing

In his dissection of the FDAs effort to scientifically validate the benefits of the warning labels, Boston University Professor Michael Siegel echoed the regulators findings: The primary analysis upon which the FDA bases its conclusion actually demonstrates no significant effect of the regulation. He emphasized that the FDAs analysis suggests a further deterioration in the science being used by anti-smoking groups and even federal agencies involved in tobacco control. In a further rebuke, Siegel explained that this episode adds to the evidence that anti-smoking groups are grossly exaggerating any likely effects of the new cigarette warning labels

However, challenges remain in areas such as disposing of seized products, preventing smuggling, and stopping surrogate advertising