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Overdose with methadone can cause nausea, vomiting, severe respiratory depression, and serious cardiac symptoms with dangerous arrhythmias (Torsades de Pointes arrhythmias, prolonged QT interval)

10a is the direct result of the flow rate rather than the systematic reduction in the smouldering period (28 s for the 2-s puff, 27 s for the 3-s puff and 26 s for the 4-s puff), or the systematic reduction in the length of the tobacco rod burnt during smouldering, as the 26-s smouldering period produced the most significant smoulder peak

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