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Interestingly enough, a study found that freebase nicotine liquids can achieve a higher blood-nicotine level (2), indicating there could be advantages to freebase nicotine liquids including needing to vape less frequently, which in turn means spending less money and prolonging the lifetime of your rechargeable batteries, prefilled pods and e-liquid bottles

Whether this compositional shift translates to higher lung cancer risk remains unsettled: Conventional observational studies are inconsistent and rarely stratify by potency, but Mendelian randomization (MR) analyses suggest a possible causal signal for lung cancer (and specifically squamous histology) with genetic liability to cannabis use/use disorder (65,66)