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Introduction Direct involvement of chemicals in the tobacco smoke with cancer has been shown since the 1970s and considered as pleiotropic carcinogens that cause DNA damage ( In this study, we will highlight genomic and molecular features, which can be used to develop approaches to predict cancer after long-term tobacco smoke exposure

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In Minnesota, a study found that daily smoking among young adolescents dropped by 28% in 14 communities that implemented comprehensive tobacco retailer licensing ordinances, and successful youth purchases dropped form 39% to 5%

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