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Chewing too much can lead to hazy vision, stomach pain, diarrhoea, cold sweats, dizziness, difficulties hearing and breathing, fainting, exhaustion, low blood pressure, headache, nausea, pallor, mental confusion, fast and irregular pulse, an excessive amount of saliva, "the shakes," and vomiting

Sub-group analysis and sensitivity analysis were not considered with the high heterogeneity levels in the study

Interestingly, epidemiological data indicated an inverse association between smoking and ulcerative colitis, suggesting complex tobaccomicrobiota interactions that merit further study [104]

Support for minimum legal sales age laws set to age 21 across Australia, Canada, England and US: Findings from the 2018 ITC Four Country Smoking and Vaping Survey