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Sample size For a Williams crossover design with three products and six sequences, and an overall standard deviation (SD) of paired differences of 0.129 (comparable to an intra-participant coefficient of variation [CV] of 13%), it was calculated that a minimum of 30 participants would be needed to detect an 11% (0.11) difference between mean values with a statistical power of at least 80% and a significance level of 5%

These PUFAs deteriorate without visible smoking, so the fact that they have a high smoke point is actually a detriment in this regard

Starting in the 1950s and lasting at least through 2006, different tobacco companies "at different times and using different methods, have intentionally marketed to young people under the age of twenty-one in order to recruit 'replacement smokers' to ensure the economic future of the tobacco industry." 5