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They were invented in the 1880s as a treatment for sore throats and asthma

They were downgraded to fourth-line in 2006 because they do not perform as well as other drugs, particularly in the elderly, and there is increasing evidence that the most common beta blockers at usual doses carry an unacceptable risk of provoking type 2 diabetes

As the results indicate, the removal efficiency of both membranes for all three studied metals was near 90% because when concentration polarization occurs, the selective character of the membrane can effectively remove heavy metals 59