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Other clinical trials testing the efficacy of e-cigarettes for smoking cessation are ongoing, but existing data are far too sparse to recommend e-cigarettes as a first- or even second-line medication for smoking cessation

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Nicotine, the addictive substance in tobacco, can lead to temporary mood enhancement, but this is often followed by increased anxiety, irritability, and depression as the effects wear off

The nicotine binds to those alpha-4 beta-2 nicotinic receptors, helping to keep you from experiencing withdrawal when you go longer and longer without having your regular tobacco product