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Genetic factors significantly influence both smoking initiation and persistence, a schematic of these influences are presented in Figure 1, these include genes associated with differences in nicotine's metabolic capacity and nicotine effects on central nervous system neurotransmitter functionality, specifically the dose that modulate direct and indirect effects on nAChR, dopaminergic and opioidergic activity, respectively

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This parameter was included in the model as a mediating variable, as it was influenced by the drug used in smoking cessation treatment