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They note that smoking has a damaging effect on the integrity of a persons DNA, and that instability within an individuals genome is one of the factors that contributes to the development of cancer

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WeirHKAndersonRNKingSMSomanAThompsonTDHongYet alPeer reviewed: heart disease and cancer deathstrends and projections in the United States, 19692020

In 2016, when FDA finally deemed e-cigarettes as part of its jurisdiction, it gave e-cigarettes that were currently on the market two years to prepare premarket applications (known as PMTAs)