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After reviewing the companys PMTAs, the FDA determined that the applications lacked sufficient evidence to demonstrate that permitting the marketing of the products would be appropriate for the protection of the public health, which is the applicable standard legally required by the 2009 Family Smoking Prevention and Tobacco Control Act

Not enough studies have been conducted to give a definitive answer about the risks or lack thereof

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And that's just cardiovascular effects -- other researchers are still exploring the relationship between marijuana smoke and long-term cancer risk