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According to the World Health Organization (WHO), 7 million people die from smoking every year

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To assess the most significant among these, this paper follows the guidelines of Fowles and Dybing ( 6 ), who suggested identifying chemical components with the greatest potential for toxic effects, specifically those associated with cancer, respiratory, and cardiovascular diseases

Results The published scientific literature and unpublished internal tobacco company research can be grouped by laboratory experimental data (ie, impact of filter ventilation on smoke chemistry yields, in vitro mutagenicity, and in vivo animal studies) and human studies (ie, smoking behavior, exposure including observational studies and clinical trials, and long-term epidemiology)