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Vaping Weed: Know the Facts How marijuana affects you depends, in part, on a few factors: How much you use Frequency of use If you take it with alcohol or other drugs Concentration of tetrahydrocannabinol ( THC : a psychoactive compound that causes a high) and cannabidiol ( CBD : a psychoactive compound that doesnt cause a high) The long-term impacts of cannabis are still being researched, but so far, studies are indicating that cannabis use can lead to memory, learning and mental health problems, especially in children and teenagers