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The wrapper makes up most of the flavor, while the other ingredients might embolden those flavors or add more

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Similarly, prior 48 reported that persistent smokers had a significantly higher 10-year cumulative incidence of COPD compared to nonsmokers, with an OR of 5.37 (95% CI: 2.7510.48) using BTS criteria and OR of 4.56 (95% CI: 2.588.07) using GOLD criteria