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Effects on the Unborn Child Smoking during pregnancy increases the risk for: Low birth weight Premature birth, which in turn increases the risk for many other health problems Stillbirth Birth defects (women who smoke during pregnancy have lower levels of folate, a B vitamin that is important for preventing birth defects) Obesity and diabetes Cleft lip (a split lip that has not closed during the fetus' development) Some women have genes that may make them especially likely to deliver low-birth-weight infants if they smoke, although newborns of all female smokers are at greater risk for low birth weight