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[121] : 322 Windows-based IBM-PC clones also led to the development of additional GUIs such as IBM's TopView or Digital Research's GEM, [121] : 322 and thus "the graphical user interface was beginning to be taken for granted, undermining the most apparent advantage of the Mac...it seemed clear as the 1980s wound down that Apple couldn't go it alone indefinitely against the whole IBM-clone market"

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In fact, one might have expected the switch to cigarettes delivering low tar to have reduced the hazard of lung cancer, but this effect is being offset by the maturing of the smoking epidemic, and thus smokers still alive in more recent years have had a longer history of regular consumption of cigarettes than men of the same ages would have had during the 1950s and 1960s

Common triggers of eczema include: Exposure to extreme heat or cold Certain soaps, shampoos, and body washes Fabrics such as wool or polyester Candle fragrances Metals such as nickel Dust mites