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Nicotine has been shown to inhibit the accumulation of tetraethylammonium (a model substrate for OCTs) in a human embryonic kidney cell line (HEK-293), mediated by OCT1 with an IC50 of 63 M and by OCT2 with an IC50 of 50 M in vitro (Urakami et al., 1998)

Evidence from a study in England covering elections across three decades, as well as studies from Ireland, US and Sweden, all demonstrate a strong relationship with intending not to vote and smoking [1, 3, 18, 32]