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Among the other drug efflux ATPase genes previously reported to contribute to cisplatin resistance ABCG2, ABCC2, ABCA1 , and ABCC1 were significantly up-regulated in at least one cell line (Figure S3cf), while ATP7B was unchanged after exposure to e-cigarette aerosol extract (Figure S3g)

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The increase in absolute lifetime cancer risk for consuming ten cigarettes per week compared with ten units of alcohol for women however was comparable (1.5% AR per ten cigarettes, 1.4% AR per ten units of alcohol) as a result of breast cancer incidence being partly driven by alcohol (Additional file 1: Table S4)

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