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Among this core response were polycyclic aromatic hydrocarbon metabolizing genes (e.g., CYP1B1 ), S100 family genes (known to regulate immune homeostasis and tissue repair), markers of squamous metaplasia (e.g., KRT14 and KRT17 ), and interferon and chemokine inflammatory signaling (Fig

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The mood was one of white-knuckled gallows humour: this was the existential crisis that every film-maker fears, made worse because Apocalypse was already over schedule and budget, and Francis had staked his personal fortune as collateral to make up the difference