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Likewise, in human bronchial cells, it has been shown that TS induces increased AP-1 activity, promoting aberrant c-Jun/Fra1 dimerization, which is linked with aberrant phenotypical changes such as hyperplasia, epithelial-mesenchymal transition (EMT), release of EGF ligand, and cell transformation [119,120]

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Recommended for beginners of heat-not-burn tobacco Bright menthol Fragrance: , richness: , menthol strength: A citrus flavored menthol that has a strong refreshing sensation but is not spicy

25 September 2017