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PI3K/mTOR inhibition attenuates cigarette smoke-induced senescence and SASP in oral fibroblasts: implications for tumor microenvironment remodeling Nicla Flacco, Cristina Estornut, Ins Roger, Pilar Ribera, Germn Snchez-Herrera, Silvia Trujillo-Barbera, Martn Prez-Leal Frontiers in Cell and Developmental Biology 30

Studies show that most users consume chewing tobacco multiple times a day, often during downtime or while performing physical labor.Interestingly, patterns of use also reveal seasonal trends

Previous studies have reported nicotine-induced tissue hypoxia in the aortic wall, potentially linked to endothelial dysfunction 32,33