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Factors that compromise ones immune system and have been linked to increased risk of mouth ulcers include: Poor diet in particular deficiencies in Iron, Vitamin B12 or Vitamin C Lack of sleep Stress Autoimmune diseases (including HIV) Viral infections (including Oral Herpes- although this is more commonly associated with cold sores) Excessive alcohol consumption Spirits can also damage tissue in the mouth on contact Undiagnosed food intolerances Smoking hot smoke can also damage tissue in the mouth on contact As ulcers often occur as the result of infection from plaque bacteria on the teeth, poor oral hygiene also plays a contributory role in the development of mouth ulcers