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A spectrum of multi-omic alterationsincluding genomic, epigenomic, epitranscriptomic, and metabolomic changes, as well as dysregulated signaling pathwayscontribute to malignant transformation, immune evasion and tumor progression [11, 55]

Table 18 below shows the incidence of MACE and Hazard Ratios compared to placebo for all randomized subjects exposed to at least 1 partial dose of study treatment in the parent study

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