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Procedure After reviewing and signing a consent form, participants completed a baseline questionnaire including information about basic demographic characteristics (age, gender, educational attainment, income, racial background)

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If p53 is mutated, unable to function as a transcriptional regulator, and unable to mediate apoptosis, cells can continue to divide without DNA repair, chromosomal damage may occur and magnify with each cell division, and neoplasia can ensue (see Figure 2)

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